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Bioreactor, BIOR-M Series

Model : BIOR-M1; BIOR-M2; BIOR-M3; BIOR-M5L; BIOR-M7; BIOR-M10; BIOR-M15

Total Volume (L): 1/2/3/5/7/10/15
Flow Meter: 2 rotameters
Gas Source: Air, O2
Material (Vessel): Borosilicate 3.3 glass
Temperature Range: 0~150.0 °C
PH Range: 2.00~12.00
DO Range: 0.0~150.0%
This bioreactor offers you a fast and convenient standardized microbial culture solution, with simple operation and quick assembly. It is suitable for suspension and adherent cell culture processes, as well as for PD scale to full cGMP production workflows.

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Product Description

Bioreactor Features:

1.Cost-effective and Non-redundant: Standardized solution for microbial cultivation.

2. Intuitive Interface: 10.1-inch touch screen with graphical design language, making operation no longer complicated.

3.Quick and Easy Installation: Small footprint and no tools are required for installation.

4. Mature Vessel Manufacturing Process: All components are located on the vessel lid, easy to disassemble, maintain and clean.

5.Reliable Performance and Precise Control: Leading international brands core hardware ensures stability.

6. Versatile Total Volumes: 7 options from 1 L to 15 L for diverse scales.

7. Powerful Software Functions: Full control via feedback, time, conditions, scripts, etc.

8.Easy Sterilization: The separation of the base, vessel body and stirring motor enables a lightweight design, making it easier for experimenters to transfer it to the sterilizer.

9. Remote Communication: Wired and wireless LAN for remote monitoring and control.

10.Ready to Use after Installation: The complete kit includes everything needed for the application, pre-configured, and ready to use, without the need to purchase additional accessories.

11. Flexible Customization: Extensive upgrades and bespoke solutions for special needs.

Bioreactor Speciﬁcations:

Model

BIOR-M1

BIOR-M2

BIOR-M3

BIOR-M5L

BIOR-M7

BIOR-M10

BIOR-M15

Housing Material

Carbon steel, plastic powder coating

Display

10.1" color touch screen

Controller

Siemens S series PLC, MCGS HMI

Integrated Pump

4 fixed-speed fast-loading peristaltic pumps

Flow Meter

2 rotameters

Communication

USB (software upgrade, data copy and export), Industrial Ethernet, WiFi

Interface

1 x pH sensor cable; 1 x DO sensor cable; 2 x stirring motor control wires;

1 x temperature sensor interface; 1 x foam sensor cable;

1 x heating base control wire interface; 1 x main power interface

Independent Control Tower

Water Interface

6 × hose barb fitting (inlet/outlet for exhaust condenser, base jacket and chilled water)

Air Interface

3 × hose barb fitting (2 x gas supply interface, 1 x gas outlet)

Power Supply

220V (±10%), 50Hz, single phase

Rated Power

400 W

600 W

800 W

900 W

1500 W

External Size (WxDxH)

360×500×720mm

Net Weight

Approx. 40 Kg (depending on configuration)

Motor

Maintenance-free, low noise servo motor

Agitation Control

Speed Range

5 - 1000 rpm

Speed Accuracy

± 0.5%

Rated Power

200 W

400 W

750 W

Gas Source

Air, O2

Control Method

Air: rotameter; O2: rotameter + solenoid valve

Gas Control

Gas Inlet

Ring sparger

Flow Range

Sparger - Air: Max. design 2 vvm; Sparger - O2: Max. design 1 vvm

Flow Accuracy

± 4%

Control Method

Robust PID algorithm

Heating Method

Closed loop system with circulating jacket, bottom electric hot plate

Heating Power

80 W

200 W

330 W

550 W

Temperature Control

Cooling Method

Tap water or circulating cooling water

Sensor

Pt100 RTD (JUMO, German)

Measurement Range

0~150.0°C

Measurement Accuracy

± 0.1°C

Control Range

8.0 °C above coolant to 40.0 °C above ambient (0-65.0 °C absolute)

Control Accuracy

± 0.2°C

PH Control

Control Method

· Robust PID algorithm · Cascade control with peristaltic pumps by adding acid and alkali

Sensor

Hamilton Sterilizable Gel-filled pH electrode

Measurement Range

2.00~12.00

Measurement Accuracy

0.01

Control Accuracy

± 0.05

DO Control

Control Method

· Robust PID algorithm · Cascade control with different parameters (agitation, gas flow and pump)

Sensor

Hamilton Sterilizable polarographic DO electrode

Measurement Range

0.0~150.0%

Measurement Accuracy

0.10%

Control Accuracy

± 3%

Foam Control

Control Method

· Cascade control with peristaltic pump by adding antifoam (defoamer) · Mechanical defoaming blade

Bioreactor Speciﬁcations (Glass Vessel) :

Model

BIOR-M1

BIOR-M2

BIOR-M3

BIOR-M5L

BIOR-M7

BIOR-M10

BIOR-M15

Glass Vessel

Type

Single-wall flat-bottom cylindrical vessel, available for heating base

Total Volume

1 L

2 L

3 L

5 L

7 L

10 L

15 L

Max. Working Volume

0.75 L

1.5 L

2.25 L

3.75 L

5.25 L

7.5 L

11.25 L

Min. Working Volume

0.25 L

0.5 L

0.75 L

1.25 L

1.75 L

2.5 L

3.75 L

Material (Wetted Part)

· Glass vessel material: Borosilicate 3.3 glass

· Vessel cover and inner parts: SUS 316L

· Seal: EPDM and Silicon

Surface Treatment

· Inner surface: electrolytic polishing, Ra ＜0.4 μm

· Outer surface: Ra ＜0.6 μm

Pressure Design

Working pressure: 0~1 bar @ 150°C Autoclavable

Height to Diameter Ratio [H: D]

Approx. 2:1

Vessel Dimensions

Refer to "Table A"

Vessel Weight (Excluding Motor)

8 kg

10 kg

11 kg

13 kg

15 kg

17 kg

20 kg

Base Weight (With Bottle Holder)

8 kg

10 kg

15 kg

Vessel Lid Interface

1 × Agitator flange for top mechanical stirring; 1 × Flame inoculation port;

2 × Baffle port, including cooling coil; 1 × Gas inlet port for ring sparger;

1 × Exhaust port, including water-cooled exhaust condenser; 1 × PH sensor port;

1 × DO sensor port; 1 × PT100 temperature sensor port; 1 × Foam sensor port;

1 × Sampling port; N × Feeding port;

Impellers

· < 5 L: 2 layers, top: foam breaker, bottom: 6-blade Rushton impeller

· ≥ 5 L: 3 layers, top: foam breaker; middle: 4-blade pitched impeller; bottom: 6-blade Rushton impeller

Baffles

· <3 L: 2 removable baffles · ≥ 3 L: 4 removable baffles

Table A:

Dimension
Vessel Volume	1 L	2 L	3 L	5 L	7 L	10 L	15 L
a (mm)	448	540	637	656	736	840	888
b (mm)	360	430	470	486	522	616	700
c (mm)	205	254	270	286	368	430	470
d (mm)	170	230	230	240	315	380	420
e (mm)	Ø90	Ø110	Ø140	Ø170	Ø170	Ø185	Ø216
f (mm)	156	156	187	220	220	240	275
g (mm)	210	210	248	267	267	300	340
Sterilization Requirement
Minimum Size (mm)	Ø195×365	Ø195×450	Ø230×475	Ø270×500	Ø270×590	Ø275×645	Ø320×710
Recommended Size (mm)	Ø260×400	Ø260×500	Ø300×555	Ø300×555	Ø330×650	Ø330×650	Ø370×750